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Sex differences in experimental pain have been evaluated using a wide range of stimulus modalities including pressure, electrical, ischemic, thermal, and other models of experimental pain (eg, chemical). Dynamic models of experimental pain have been used to engage systems underlying summation and inhibition of pain. Pain sensitivity has been assessed by a number of different outcome measures including behavioral indices of threshold (defined by time or intensity to the first sensation of pain) and tolerance, and self-report measures of pain intensity and unpleasantness. Previous reviews have concluded that females are more sensitive to pain compared with males.127,327 The following review will determine whether more recent studies continue to support this conclusion.
- This review of recent clinical and epidemiologic findings generally indicates that women are at increased risk for many chronic pain conditions, and women tend to report higher levels of acute procedural pain.
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- Preliminary evidence suggests that low testosterone levels may be a risk factor for cognitive decline and possibly for dementia of the Alzheimer’s type,[47][48][49][50] a key argument in life extension medicine for the use of testosterone in anti-aging therapies.
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